Abstract:Autonomic dysregulation plays an important role in the pathogenesis of ventricular arrhythmias. Neural feedback loop of different levels links heart and the nerve center. Cardiac disease leads to cardiac neural remodeling and autonomic dysregulation, which could regulate cardiac electrical activities at the autonomic nervous center and peripheral levels. This review discusses the recent applied research advances in neuromodulation techniques for refractory ventricular arrhythmias caused by hereditary and structural heart diseases. It aims to promote basic research of neurocardiology to adapt to the needs of clinical practice.