Abstract：Objective To investigate heart rate variability and target organ damage in patients with resistant hypertension Methods Patients with resistant hypertension (n=30) and non-resistant hypertension(n=32) were prospectively collected when a control group composed of 36 healthy subjects were also usedThe heart rate variability index and target organ damages were compared among 3 groups by 24hour dynamic electrocardiogram (ECG) monitoring Results Compared with the control group, the indexes of heart rate variability in time domain and frequency domain of the resistant hypertension group and the nonresistant hypertension group were statistically significant (P<0.05), indicating that the heart rate variability was decreased Compared with the nonresistant hypertension group, rMSSD and pNN50 in the resistant hypertension group were significantly decreased (P<0.05), and other indexes of heart rate variability were also decreased, but the difference was not statistically significant (P>0.05)Compared with the nonresistant hypertension group, the estimated glomerular filtration rate of patients in the resistant hypertension group was decreased significantly, and the thickness of ventricular septum was increased significantly (P<0.05)；carotid plaque was also increased, but the difference was not statistically significant (P>0.05)Conclusion Heart rate variability is significantly decreased in patients with resistant hypertension, and the target organ damages is more serious
