Abstract：As bioactive compounds, n-3 polyunsaturated fatty acids(n-3 PUFAs) contribute to human health through lowering serum triglyceride, and regulating heart rate and blood pressure. They also have potential anti-arrhythmia effect. Atrial fibrillation(AF) is the most commonlyseen sustained arrhythmia, which could lead to changes in atrial structure and function. In recent years, many studies have shown that n-3 PUFAs can affect the physicochemical properties of myocardial cell membranes, regulate the interaction of membrane channel proteins and the expression of transcription factors, and thus influence the electrophysiological characteristics of myocardial cells. Additionally, n-3 PUFAs play a direct or indirect anti-AF role by regulating the function of ion channels in the cell membranes and thus reducing atrial electrical remodeling.
