Abstract：T wave alternation (TWA) refers to the alternation of T wave shape, polarity and amplitude on the surface electrocardiogram during the regular rhythm. Since the mechanism of its occurrence is still unclear,the diagnostic criteria of TWA is not uniform and the clinical tests are not easy to be found, which limit the application of TWA in the clinical practice. In this paper, referring to many literature, we make a comprehensive review on the development history, diagnostic criteria, mechanism and clinical application of TWA, providing a new direction for clinical research in future.
