Abstract:P-wave axis is a practical electrocardiographic parameter which presents the direction (angle) and size (length) of the atrial depolarization vector on the frontal plane. The normal reference range of P-wave axis is 0°~+75°. Abnormal P-wave axis is associated with the increasing risk of atrial fibrillation(AF), as a result, it is always used for the followup of patients treated by radiofrequency ablation of AF. In addition, abnormal P-wave axis is also used for the assessment of risk of AFrelated ischemic stroke, screening chronic obstructive pulmonary disease, and affecting allcause mortality and cardiovascular mortality. In this review, research progress of P-wave axis is summarized.