（1.Qigong Institute，Shanghai University of Traditional Chinese Medicine，Shanghai 200030; 2.Cardiovascular Institute，the First Affiliated Hospital of Liaoning Medical College，Jinzhou Liaoning 121001，China; 3.Irvine School of Biology，University of California，CA 92697，USA）
Abstract：Objective To discuss the relationship between cycle and morphological characteris tics of nighttime respiratory method and heart rate variability. Methods Standard instructions were given to 66 testers to control uniform respiration frequency of 5 breath/min，10 breath/min and 15 breath/min，and electrocardiograph waves and respiratory waves were synchronous recorded by dynamic physiological parameter recorder. Results Cycle of respiratory regulation was fully synchronized with RR interval. Four types of respiratory methods were found: continuous regular respiratory rhythm，spindle-shaped respiratory rhythm，single irregular respiratory rhythm and continuous irregular respiratory rhythm. Conclusions Continuous regular respiratory rhythm and spindle-shaped respiratory rhythm were corresponded to the description and mechanism of respiratory sinus arrhythmia. Single irregular respiratory rhythm and continuous irregular respiratory rhythm were not corresponded to the description and mechanism of respiratory sinus arrhythmia，other mechanisms of sinus arrhythmia might exist. Therefore，more discussion are necessary to find out whether HRV changes caused by respiratory can fully reflect cardiovascular autonomic nerves balance adjustment changes.
［1］龙开平，刘一挥，杨继庆.心率变异性与呼吸的重现量化分析研究［J］.中国现代医药杂志，2007，9（1）: 5-6. ［2］沈仲元，Shin Lin，余平，等.调节呼吸频率对心率变异的影响［J］.实用心电学杂志，2009，18（5）: 323-325. ［3］刘雪红，王克强，李川勇.呼吸对心率变异性的影响［J］.国际生物医学工程杂志，2006，29（1）:56-59. ［4］陈洪波，刘仁光，沈仲元.呼吸频率和潮气量对兔心率变异的影响［J］.中国心脏起搏和心电生理杂志，2011，25（3）: 258-261. ［5］王步青，张政波，王卫东.引导呼吸下的呼吸性窦性心律不齐的研究［J］.生物医学工程学杂志，2012，29（1）: 45-51. ［6］孙聪聪，张政波，王步青，等.呼吸性窦性心律不齐定量分析研究进展［J］.生物医学工程学杂志，2011，28（6）: 1127-1131. ［7］ Denver JW，Reed SF，Porges SW. Methodological issues in the quantification of respiratory sinus arrhythmia［J］.Biol Psychol，2007，74（2）:286-294. ［8］ Eckberg DL. Point: counterpoint :Respiratory sinus arrhythmia is due to a central mechanism vs. respiratory sinus arrhythmia is due to the baroreflex mechanism［J］.J Appl Physiol，2009，106（5）:1740-1742. ［9］ Chen Z，Brown EN，Barbieri R.Assessment of auto-nomic control and respiratory sinus arrhythmia using point process models of human heart beat dynamics［J］.IEEE Trans Biomed Eng，2009，56（7）:1791-1802. ［10］ Brown SJ， Mundel T， Brown JA. Cardiac vagal control and respiratory sinus arrhythmia during hypercapnia in hu-mans［J］.J Physiol Sci，2007，57（6） :337-342. ［11］ Denver JW，Reed SF，Porges SW. Methodological issues in the quantification of respiratory sinus arrhythmia［J］.Biol Psychol，2007，74（2）:286-294. ［12］朱妙章，唐朝枢，朱大年，等.心血管生理学基础与临床［M］.北京:高等教育出版社，2011:241-246. ［13］朱蕾，刘又宁，纽善福.临床呼吸生理学［M］.北京:人民卫生出版社，2008:227-255. ［14］张开滋，郭继鸿，刘海洋，等.临床心电信息学［M］.长沙:湖南科学技术出版社，2002:584-585. ［15］郭继鸿.新概念心电图［M］.北京:北京医科大学出版社，2002:344-348. ［16］应用心率变异性判断心脏交感神经兴奋性应当慎重［J］.中华高血压杂志，2008，16（12）:1057-1058. ［17］邓君曙.评估心率变异指标［J］.中华高血压杂志，2009，17（5）:392-394.
2012, Vol. 21 
