Abstract：Objective To investigate the relationship between heart rate variability(HRV) and ambulatory blood pressure variability(BPV) in patients with isolated systolic hypertension(ISH), and to observe the relevance of autonomic nerve functional lesion to ventricular hypertrophy for essental hypertensives. Methods Fifty-seven patients with ISH were enrolled as observation group(including two subgroups:hypertrophy group and non-hypertrophy group) while another 36 individuals with normal blood pressure and without left ventricular hypertrophy as control group. The two groups underwent 24-hour ambulatory electrocardiography(Holter) and 24-hour ambulatory blood pressure monitoring(ABPM) simultaneously, with related HRV and BPV indices recorded.Results The change trends of HRV and BPV were found to be opposite between observation group and control group. That was to say, HRV time domain indices of SDNN, rMSSD and pNN50% in observation group were significantly lower than those of control group while 24 h SSD was significantly higher, both with statistically significant differences(P＜0.01). Compared with that of control group, SBP value of hypertrophy group was higher in each time period, while there was no statistically significant difference between DBP value of the two groups. In addition, the incidence of 24-hour ventricular premature beat among hypertrophy group was higher than that in control group, with statistically significant difference(P＜0.01).Conclusion The relevant changes of HRV and BPV in patients with isolated systolic hypertension indicate the important role autonomic nerve functional lesion plays in the development of hypertensive left ventricular hypertrophy.
于迎根,彭颖秀,史咏秋. 单纯收缩期高血压心率变异与动态血压变异关系研究[J]. 实用心电学杂志, 2015, 24(4): 279-282.
于迎根,彭颖秀,史咏秋. Study on the relationship between heart rate variability and ambulatory blood pressure variability in isolated systolic hypertensives. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2015, 24(4): 279-282.
2015, Vol. 24 
