● Article
SU Xin-Cheng-1, Pang-Shu-Jie-1, Yang-Ning-1, Xu-Zhu-Ding-2
2015, 25(03): 241.
Objective: To describe the difference between the hepatolithiasis(HL)-positive intrahepatic cholangiocarcinoma(ICC) and hepatolithiasis-negative intrahepatic cholangiocarcinoma, and examine the prognosis based on our data. Methods: A total of 296 patients with ICC underwent the first curative resection were involved in our research, in whom 38 were with hepatolithiasis , the rest 258 were without. Data of sixteen clinicopathological features, recurrence free survival(RFS) rate and overall survival(OS) rate were collected and examined retrospectively. Results: About the sixteen clinicopathological features, the age of the HL-associated ICC patients tend to be older and with more female gender. The HL-positive group tends to have a higher level of CA19-9, ALP,r-GT. Meanwhile, the HL-positive ICC was more likely to be accompanied with satellite lesions, lymph node metastasis, nerve invasion. Moreover, the HL-positive ICC tends to have a more progressive TNM staging. The actual 1-,3-,5-year recurrence free survival(RFS) rate in the HL-positive group was 19.8%,2.6%,0% and in the HL-negative group was 46.9%，26.4%, 20.9%.The 1-, 3-, and 5-year overall survival rate was 39.5%,7.9%,0% in the HL-positive group and in the HL-negative group was 67.8%,38.0%,26.4%. Conclusion: The HLpositive ICC has a more progressive degree and a poorer prognosis compared with the HL-negative ICC. So that the HL-positive ICC were prone to form the lymph node metastasis, and lymphadenectomy in the hepatoduodenal ligament was suggested.
［Key words］intrahepatic cholangiocarcinoma; hepatolithiasis; survival
