老年男性2型糖尿病患者骨质疏松相关因素分析

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Abstract [Abstract]Objective: To study the osteoporosis-related risk factors in elderly male patients with type 2 diabetes mellitus. Methods: A total of 154 elderly male patients with type 2 diabetes were divided into three groups: normal group, osteopenia group and osteoporosis group．Bone mineral density(BMD) were measured by dual-energy X-ray absorptiometry(DXA). BMI, HbA1c, FBG, PBG, fasting C peptide, postprandial C peptide, serum calcium (Ca2+), TG, TC, LDL-C，HDL-C，serum uric acid and hs-CRP were measured． Results: The age and duration of diabetes in osteopenia group and osteoporosis group were significantly higher than those of normal group(P<0.05), while BMI in osteopenia group and osteoporosis group was significantly lower than that of normal group(P<0.01). HbA1c and hsCRP significantly increased in osteopenia group and osteoporosis group compared with normal group, while fasting C peptide, postprandial C peptide significantly decreased. There was no significant difference in FBG, PBG, serum calcium (Ca2+), TC, TG， HDLC, LDLC， and serum uric acid among the three groups(P>0.05). Conclusion: The BMD of elderly male type 2 diabetes patients may be correlated with the age, duration of diabetes and BMI. Bigger BMI may be a protective factor, while poor insulin function and poor control of blood glucose may be risk factors. In addition， inflammatory factor hsCRP may play roles in the pathogenesis of osteoporosis in elderly male type 2 diabetes patients.

Received: 20 October 2015

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2016/V26/I02/164

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