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| Changes of serum netrin-1 levels and related factors in patients with overweight/obesity |
| YANG Qi-chao1, WANG Su1, YU Shu-qin1, JIANG Dan1, LIU Yuan-xin1, XUE Hao-ying1, HONG Xia-fei1, ZHUANG Ruo1, WANG Dong1, YANG Ling1, YIN Wei1, ZHOU Li-bin2, YUAN Guo-yue1 |
| （1. Department of Endocrinology, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001; 2. Department of Endocrinology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China) |
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Abstract [Abstract]Objective: To investigate the change of serum netrin-1 level in overweight/obesity patients and investigate the relationships of serum netrin1 level with obesity, glycolipid metabolism and insulin resistance. Methods: A total of 150 Chinese subjects were enrolled in the study, including seventysix subjects with normal weight (NW) and seventyfour patients with overweight/obesity (OW/OB). NW and OW/OB groups were further divided into normal glucose tolerance (NGT) and patients with newly-diagnosed T2DM subgroups separately. OW/OB was defined as BMI≥25 kg/m2 according to the WHOWestern Pacific Region diagnostic set forth in 2000. 75 g oral glucose tolerance test (OGTT) was performed in all subjects. Waist circumference (WC), waisttohip ratio (WHR), HbA1c, blood glucose, blood insulin, blood lipids and netrin-1 level were also determined. Results: The serum netrin1 level was significantly lower in OW/OB group than that in NW group \[367.87 (268.42 to 545.09) ng/mL vs 444.95 (372.69 to 668.16) ng/mL，P<0.01\]. Subjects in the upper and middle serum netrin-1 levels had lower levels of BMI and WC, when compared to subjects in the lower serum netrin1 levels. Pearson correlation analysis showed that serum netrin-1 level was negatively correlated with BMI and WC (P<0.01), and positively correlated with age (P<0.05). Multiple linear regression analysis showed that age and BMI were independently related to serum netrin1 level(P<0.05 or P<0.01). Conclusion: Circulating levels of netrin1 were decreased in subjects with overweight/obesity. Serum netrin-1 level was significantly negatively correlated with BMI. It suggested that the netrin1 might play an important role in the pathogenesis of obesity.
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Received: 10 December 2015
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2016, Vol. 26 
