Betatrophin基因多态性与2型糖尿病的相关性

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Abstract Objective: To investigate the association between rs2278426 polymorphism of betatrophin gene and type 2 diabetic mellitus (T2DM). Methods: A total of 200 subjects with T2DM (T2DM group) and 200 healthy controls (control group) were enrolled in this study. The genotype of betatrophin SNP rs2278426 was detected by the polymerase chain reactionrestricted fragment length polymorphism (PCRRFLP). Results: The frequency of C/T+T/T genotype and T allele of rs2268388 were significantly higher in T2DM group than those in control group(P<0.05).Fasting plasma glucose and 120 min OGTT glucose (2hPG) in carriers with C/T+T/T genotype were higher than those with CC genotype. Logistic regression analysis showed that the risk of T2DM increased in betatrophin rs2278426 T allele carriers compared with those with C allele. Conclusion: The betatrophin rs2278426 gene polymorphism may be associated with T2DM.The T allele may increase the risk of T2DM.

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2019/V29/I01/72

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