Abstract：Objective:To investigate the clinical significance of combined shear wave elastography (SWE) parameters and quantitative analysis parameters of contrastenhanced ultrasound (CEUS) in the differential diagnosis of benign and malignant thyroid nodules. Methods: A total of 71 patients with malignant thyroid nodules and 65 patients with benign thyroid nodules who underwent auxiliary diagnosis in the ultrasound department of Taicang First People′s Hospital from January 2019 to January 2021 were selected. All patients underwent SWE and CEUS. The differences in twodimensional ultrasonographic appearance of benign and malignant nodules, SWE and CEUS parameters in the central area were analyzed.Logistic regression model was used to screen the parameters for judging malignant nodules in SWE and CEUS, the receiver operator characteristic (ROC) curve was drawn using pathological diagnosis as the gold standard, and the area under the curve (AUC) was calculated,and the predictive value of each factor and combined diagnosis of malignant thyroid nodules was analyzed.Results: The twodimensional ultrasonography of benign and malignant thyroid nodules had significant differences in morphology, margin, aspect ratio and microcalcification, and there were differences in central area Emin, Emean, Emax, Peak and AUCt of benign and malignant thyroid nodules (P<0.001). Logistic regression results showed that Emax and Peak entered the regression equation. The ROC curve results showed that among the SWE parameters, the area under the Emax curve was the largest and had the highest diagnostic performance, while Peak was the best diagnostic index in the CEUS parameters, and the AUC value of Emax and Peak in the diagnosis of malignant thyroid nodules was 0.837, which was greater than that of either SWE or CEUS alone.Conclusion:The diagnostic value of Emax and Peak in the central area of thyroid nodules is higher than that of other single parameters, and it has certain guiding significance for the noninvasive examination and diagnosis of thyroid nodules in clinical practice.
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收稿日期: 2022-03-10
基金资助:太仓市科技局基础研究计划（TC2018JCYL02）
通讯作者:
朱正（通讯作者）,主任医师,硕士生导师,Email:zhuzheng751213@163.com
The value of shear wave elastography parameters and contrastenhanced
