Objective: To study the relationship between the magnitude platelet decline and the prognosis in patients with early septic shock. Methods: Data of 327 patients with septic shock were collected. The percentage of platelet decline that was less than 30% or more than reference value within 48 hours was considered as control group, and that was more than 30% was enrolled in the study group. In addition, by comparing the lactate level, SOFA score, infection sites, and platelet decline ratio in the two groups, we determined to analyze the factors affecting the cumulative survival rate. Results: The 28-day cumulative survival rate was 75.5% (control group) and 9.8% (study group), respectively. Besides, the results in study group was significantly lower than that in control group (χ2=170.1, P<0.01). Both SOFA score within 24 hours and decline rate of platelet (more than 30%) were correlated with patient death by Binary logistic regression (P<0.01). Moreover, compared with the platelet count (less than 100×109/L), the ROC curve also suggested that decline rate of platelet (more than 30%) was a more specific predictive indicator. Conclusion: Patients with decline rate of platelet (more than 30%) in the early stage of septic shock may have worse prognosis.
