Abstract：Objective: To investigate the value of the serum lipoprotein associated phospholipase A2(LpPLA2) levels in the diagnosis and screening of early asymptomatic diabetic peripheral neuropathy(DPN). Methods: A total of 89 patients diagnosed with type 2 diabetes less than 12 months were divided into DPN group and nonDPN group according to neural electromyography. The diagnostic value of LpPLA2 by diagnostic test and ROC curve analysis were evaluated and the appropriate cutoff point were determined. Results: The level of serum LpPLA2 of DPN group was significantly lower than that of nonDPN group (t=-3.772, P=0.000).The area under curve(AUC) of LpPLA2 was 0.731(P=0.001). The appropriate cutoff point was 133.50 ng/mL. Conclusion: Serum LpPLA2 levels could predict DPN, but which still need further to be validated in larger sample research.
收稿日期: 2017-03-23
基金资助:
镇江市社会发展项目（SH2013089，SH2015027）
通讯作者:
任乃勇（通讯作者），主任医师，Email: rny.zj.js@163.com
作者简介: 张渭芳（1972—），女，江苏镇江人，副主任医师，主要从事脑血管病和周围神经疾病的防治
引用本文:
张渭芳， 苏岑， 赵康仁， 任乃勇. 血清Lp-PLA2含量对早期无症状糖尿病周围神经病变的筛查价值[J]. 江苏大学学报:医学版, 2017, 27(04): 324-326.
ZHANG Wei-fang, SU Cen， ZHAO Kang-ren, REN Nai-yong. The value of serum lipoprotein associated phospholipase A2 levels in screening patients with early asymptomatic diabetic peripheral neuropathy. Journal of Jiangsu University(Medicine Edition), 2017, 27(04): 324-326.
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2017, Vol. 27 
