Therapeutic effect of epalrestat combined with beraprost sodium on diabetic peripheral neuropathy
TANG Shan1, MEI Hong2, WEN Hong-hua1, LI Dan2, ZHU Qun1
（1. Department of Endocrinology, the Second Affiliated Hospital of Nanjing Medical University, Nanjing Jiangsu 210011; 2. Department of Endocrinology,the Yuejiang Tower Community Health Centre,Gulou District,Nanjing Jiangsu 210011,China)
Abstract：Objective: To investigate the therapeutic effect of epalrestat combined with beraprost sodium on diabetic peripheral neuropathy(DPN). Methods: A total of 96 patients with DPN were randomly divided into epalrestat group(n=32), beraprost sodium group(n=32) and epalrestat combined with beraprost sodium group(n=32).After 12 weeks treatment, the clinical effect and motor conduction velocity and sensory conduction velocity of median nerve, peroneal nerve were measured in three groups. Results: There were statistically significant differences in therapeutic efficacy among three groups(P<0.05), epalrestat combined with beraprost sodium in treatment of DPN exerted the best efficacy. The nerve conduction velocity of the three groups was improved compared with before that treatment(P<0.05). With regard to nerve conduction velocity improvement in three groups, epalrestat combined with beraprost sodium group had more rapid velocity than the other two groups(P<0.05). Conclusion: Epalrestat combined with beraprost sodium in treatment of DPN could produce best therapeutic efficacy.
收稿日期: 2017-03-19
基金资助:
江苏省自然科学基金资助项目（BK20151577）
通讯作者:
祝群（通讯作者），博士，副主任医师，E-mail:qun_zhu@163.com
作者简介: 唐珊（1991—），女，硕士研究生；
引用本文:
唐珊1 ， 梅红2， 温洪华1， 李丹2， 祝群1. 依帕司他联合贝前列素钠治疗糖尿病周围神经病变的疗效[J]. 江苏大学学报:医学版, 2017, 27(04): 305-308.
TANG Shan1, MEI Hong2, WEN Hong-hua1, LI Dan2, ZHU Qun1. Therapeutic effect of epalrestat combined with beraprost sodium on diabetic peripheral neuropathy. Journal of Jiangsu University(Medicine Edition), 2017, 27(04): 305-308.
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2017, Vol. 27 
