胸腺基质淋巴生成素在银屑病发病中的机制研究进展

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摘要胸腺基质淋巴生成素（thymic stromal lymphopoietin，TSLP）是一种细胞因子，由皮肤、肺和肠道等屏障部位的上皮细胞表达，可以作用于多种细胞系，影响细胞成熟、增殖、存活和募集。TSLP作为过敏性疾病的主要开关，可以驱动辅助性T细胞（T helper cells，Th）2型炎症疾病，包括特应性皮炎、哮喘等。人源性TSLP单克隆抗体已经被批准上市，用于治疗严重哮喘。然而，现在一系列的研究表明，该因子可能具有不止一种效果，它在Th1/Th17免疫反应为主的银屑病中也发挥重要作用。本文讨论了不同于以往在2型炎症范围内的TSLP，这里强调了它在银屑病中如何调节组织环境，以及分析未来应用于银屑病患者可能的潜力。

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	朱念南
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关键词 ：胸腺基质淋巴生成素, 银屑病, 信号通路, 免疫治疗, 研究进展

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收稿日期: 2022-11-02

基金资助:国家重点研发计划（2022YFC2603801）；江苏大学附属医院博士启动基金（jdfyrc201903）

通讯作者: 许辉（通讯作者），主任医师，硕士生导师，E-mail： xuhuiraian@sina.com

作者简介: 朱念南（1996—），女，硕士研究生

引用本文:

朱念南，许辉. 胸腺基质淋巴生成素在银屑病发病中的机制研究进展[J]. 江苏大学学报:医学版, 2023, 33(02): 130-134.

链接本文:

http://zzs.ujs.edu.cn/xbyxb/CN/ 或 http://zzs.ujs.edu.cn/xbyxb/CN/Y2023/V33/I02/130

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