Abstract：Objective: To investigate the effects of shortterm continuous subcutaneous insulin infusion (CSII) on serum gammaglutamyltransferase (GGT) levels in patients with newlydiagnosed type 2 diabetes mellitus, and to study the association between insulin resistance and GGT. Methods: Thirtytwo patients with newlydiagnosed type 2 diabetes mellitus were treated with CSII for 2 weeks. Oral glucose tolerance test and insulin releasing test were performed before and after intensive insulin therapy, meanwhile, blood lipid, serum GGT and other items were measured. Results: ① Two weeks of CSII treatment in type 2 diabetic patients resulted in significant reduction in fasting serum insulin［(11.60±2.89） vs(6.82±1.01)mmol/L, P<0.01］, postprandial serum insulin［(22.52±4.57）vs(13.81±3.10)mmol/L, P<0.01］ and homeostasis model assessment for insulin resistance(HOMAIR)\[2.20(1.45~3.07) vs 1.37(0.89~1.90), P<0.01\]. ② After CSII treatment for 2 weeks, the level of serum GGT was decreased significantly \[24.00(18.00~35.00) vs 18.00(16.00~27.00) U/L, P=0.005\]. ③ Serum GGT level was positively correlated with HOMAIR（r=0.418，P<0.05）. Meanwhile, changes in serum GGT levels were positively correlated with changes in HOMAIR（r=0.433，P<0.05）. ④ The multiple regression analysis showed that the HOMAIR were independent related factors in the influence of the serum GGT levels．Conclusion: In type 2 diabetic patients, elevated serum GGT levels were significantly decreased after CSII treatment. It might indicate that serum GGT plays an important role in the development of insulin resistance．
2012, Vol. 22 
