Abstract：Objective To explore the relativity between heart rate variability (HRV), related indexes of Lorenz scatter plot, and cardiac function in patients with aortic valve stenosis after transcatheter aortic valve replacement(TAVR). Methods Patients with aortic valve stenosis after TAVR were enrolled in our study. The time domain indexes of HRV (SDNN, SDANN, rMSSD, pNN50 and HRV triangular index), and frequency domain indexes of HRV (HF, LF and LF/HF) were compared before and 3 months after surgery. We compared the morphology of Lorenz scatter plot,and its projection length of L in the x-axis and dispersion of D in the y-axis before and after surgery. The indexes of cardiac function including LVEF, left ventricular end-diastolic diameter (LVEDD) and left ventricular endsystolic diameter (LVESD), and NT-proBNP level were compared before and after surgery. ResultsThe values of SDNN, SDANN, HRV triangular index and L -are higher after TAVR while D value is lower after surgery, with statistically significant differences (P＜0.01). LF and HF show a tendency to improve after surgery, but there is no statistically significant difference as compared to those before surgery. The time domain indexes of HRV are significantly improved after TAVR; parts of HRV indexes are positively correlated with LVEF, and negatively correlated with NT-proBNP level, LVEDD and LVESD. Conclusion The functional status of the autonomic nervous system is improved in patients with aortic valve stenosis after TAVR. HRV changes are associated with cardiac function.
