Abstract：Doxorubicin (DOX) is widely applied in hematologic and solid tumor chemotherapy, which greatly prolongates the survival time of cancer patients. However, at the same time, the accumulation of DOX in noncancer tissues also causes “offtarget effect”, that is chemotherapyrelated toxicity, among which doxorubicininduced cardiotoxicity (DIC) is the most significant and fatal. However, there is no effective means to diagnose and treat DIC at present. In recent years, studies on exosomes have been in the ascendant. The advantages such as heterogeneity, stability and nonimmunogenicity make exosomes ideal diagnostic markers and therapeutic vectors for many diseases. This article mainly aims to review the related studies on the diagnosis and treatment of DIC by non-coding RNA in exosomes.
田超，吴钦超，褚现明. 外泌体非编码RNA诊治阿霉素心脏毒性的研究进展[J]. 实用心电学杂志, 2022, 31(4): 243-248.
TIAN Chao, WU Qinchao, CHU Xianming. Advance in research on diagnosis and treatment of doxorubicininduced cardiotoxicity by exosomal noncoding RNA. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2022, 31(4): 243-248.
