Abstract：In order to prepare a new sustained and controlled release drug carrier, the chitosan nanoparticles were prepared by inverse miniemulsion crosslinking technique with vacuum dehydration treatment. The mixture solution of paraffin and hexane was used as oil phase with chitosan solution as aqueous phase, Span-80 as emulsifier and glutaraldehyde as crosslinking agent. The characteristics of the chitosan nanoparticles were determined by particle diameter distribution, SEM, FT-IR, TG and DSC. The results show that the nanoparticle size is decreased with the increasing of shear rate and content of crosslinking agent. With the increasing of the emulsifier content, the nanoparticle size is rapidly decreased at first with later slight increasing. The nanoparticle size is small when the volume ratio of oil to water in the range of 3∶2~2∶3. SEM confirms that the chitosan nanopartices have fissuaring structure and good dispersion with particle size from 100 nm to 300 nm.
2014, Vol. 35 
