Abstract: To meet the demand of lightweight for an electric bus, the body frame simulation was ensured with good structural performance under four limit conditions of horizontal bending, ultimate torsion, emergency turn and emergency braking. By sensitivity analysis, the components of chassis frame were obtained to effectively reduce the quality with slight effect on the performance of chassis structure. With the profile thickness as design variables, the minimum total frame quality as goal and the maximum displacement under different working conditions as constraints, the multi objective optimization mathematical model of body frame was established. By response surface method(RSM), the design variables of the thickness values were obtained after the optimization. The model and the structure performance of lightweight body frame under the same conditions were comparatively analyzed. The results show that the strength and the stiffness of body frame can be guaranteed under four limit conditions, and the modal frequency is also within the required range. The total weight of body frame is reduced by 456 kg, which is about 536% of the total mass.