Journal of Jiangsu University(Medicine Edition)

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Journal of Jiangsu University(Medicine Edition)

	2015 Vol.25 Issue.05 Published 2015-09-30

Article

	369	Treatment of adeno-associated virus mediated ADNF-9 gene transfection on guinea pig cochlea deafened by kanamycin
		JING Yang1, ZHENG Guo-xi2, ZHU Kang2, LIU Hui1, ZHANG Wen1
		Objective: To observe the effect of rAAVNT4ADNF9 in treating ototoxicity associated with aminoglycoside antibiotics. Methods: The guinea pigs were used,and its auvicle reflex and auditory brainstem response(ABR) were normal.The ototoxic animal model of guinea pigs were made by the method of hypodemic injection of Kanamycin(400 mg/kg).In animals under general anesthesia,the guinea pigs were cut off the skin of ringt ear sulcus posterior and opened acoustic capsule,then injected the rAAVNT4ADNF9 10 μL from fossula rotunda.After 14 days,the right acoustic capsule were dislodged. The cochlear were stained with AgNO3.The cochlear hair cells were observed by contrast phase microscope. Results: Taking the group for rAAVNT4ADNF9 as example, the threshold ABR decreased remarkably after treatment(P＜0.05). Through the phase contrast microscope the cochlear basilar membrane was complete and the outer hair cells had dot deletion. The thresholds of ABR had no notable differences for the other three groups before and after treatment. Taking comparison between the artificial endolymph control group and empty vector group, through the phase contrast microscope after treatment, hair cells showed a patchy loss in the former group and there was no such phenomenon in the latter group. The average number of hair cells observed in the group of ADNF was significantly higher than that of the artificial endolymph control group and empty vector group(P<0.05). Conclusion: rAAVNT4ADNF9 is able to be transfected into cochlear,and to express secretory NT4ADNF9 peptide,which preventing hair cells from impairment.
		2015 Vol. 25 (05): 369-372 [Abstract] ( 671 ) [HTML 1KB] [ PDF 1578KB] ( 1555 )

	373	The rabies virus glycoprotein recombinated Newcastle disease virus induce the human stomachal adenocarcinoma autophagy
		WANG Mu-bin1, YAN Yu-lan2, ZHANG Zhi-jian3, ZHAO Ying-hai1, LI Mi1, BU Xue-feng1

		2015 Vol. 25 (05): 373-377 [Abstract] ( 450 ) [HTML 1KB] [ PDF 1610KB] ( 1633 )

	378	Effect of triggering receptor expressed on myeloid cells-1 expression on the oxidative stress of intestinal macrophages in rats
		HU Rong1, WU Chaoyang1， DANG Shengchun2, CUI Lei2,

		2015 Vol. 25 (05): 378-381 [Abstract] ( 505 ) [HTML 1KB] [ PDF 981KB] ( 1617 )

	382
		LIAN Xiao-yi, SONG Ping, ZHEN Jin-xu

		2015 Vol. 25 (05): 382-385 [Abstract] ( 531 ) [HTML 1KB] [ PDF 1295KB] ( 1911 )

	386	cGMP-dependent protein kinases inhibit cisplatin resistance of lung cancer cell line A549/DDP
		PANG Ji, LAN Ting, WU Yan, CHEN Yong-chang

		2015 Vol. 25 (05): 386-389 [Abstract] ( 509 ) [HTML 1KB] [ PDF 911KB] ( 1569 )

	390	Effects of miR205 overexpression on biological behaviors in glioblastoma U-87 cells
		CHEN Wang-wang 1, FANG Jian-kai2, SUN Li1, SUN Mao-min3

		2015 Vol. 25 (05): 390-394 [Abstract] ( 647 ) [HTML 1KB] [ PDF 1788KB] ( 1352 )

	395	Effects of miR-145 expression on the invasion of glioma U251 stem cells
		LI Xiao-liang1, WANG Cun-zu2

		2015 Vol. 25 (05): 395-398 [Abstract] ( 527 ) [HTML 1KB] [ PDF 1275KB] ( 1507 )

	399
		DING Hui, CHEN Ru-hua, TANG Zhi-wei, MA Tie-liang, LU Qin, FEN Yan

		2015 Vol. 25 (05): 399-384 [Abstract] ( 477 ) [HTML 1KB] [ PDF 958KB] ( 1465 )

	404


		2015 Vol. 25 (05): 404-408 [Abstract] ( 384 ) [HTML 1KB] [ PDF 1188KB] ( 1897 )

	409	Effect of adiponectin on the expression of NLRP3 inflammasome and inflammatory factors in LPSinduced RAW264.7 macrophage


		2015 Vol. 25 (05): 409-411 [Abstract] ( 586 ) [HTML 1KB] [ PDF 847KB] ( 1839 )

	412
		ZHANG Hui, SHAO Dong-hua, WU Jin, ZHANG Wei,WANG Hua

		2015 Vol. 25 (05): 412-415 [Abstract] ( 478 ) [HTML 1KB] [ PDF 907KB] ( 1666 )

	416
		WEI Yu-he, SHAO Xue-jing, FEN Xiao-fen, ZHAO Zhi-yong, YIN Yong

		2015 Vol. 25 (05): 416-419 [Abstract] ( 578 ) [HTML 1KB] [ PDF 821KB] ( 1624 )

	420
		TANG Ying1, LIU Guo-ping2, FENG Ya-min1, LUO Fen1, MA Ying-chun3, ZHU Qun1

		2015 Vol. 25 (05): 420-424 [Abstract] ( 535 ) [HTML 1KB] [ PDF 805KB] ( 1612 )

	425


		2015 Vol. 25 (05): 425-430 [Abstract] ( 436 ) [HTML 1KB] [ PDF 1174KB] ( 1576 )

	431


		2015 Vol. 25 (05): 431-434 [Abstract] ( 446 ) [HTML 1KB] [ PDF 735KB] ( 1817 )

	435


		2015 Vol. 25 (05): 435-437 [Abstract] ( 440 ) [HTML 1KB] [ PDF 723KB] ( 1417 )

	438


		2015 Vol. 25 (05): 438-439 [Abstract] ( 398 ) [HTML 1KB] [ PDF 920KB] ( 1759 )

	440


		2015 Vol. 25 (05): 440-441 [Abstract] ( 455 ) [HTML 1KB] [ PDF 714KB] ( 3279 )

	442


		2015 Vol. 25 (05): 442-443 [Abstract] ( 422 ) [HTML 1KB] [ PDF 767KB] ( 1006 )

	444


		2015 Vol. 25 (05): 444-446 [Abstract] ( 357 ) [HTML 1KB] [ PDF 726KB] ( 1681 )

	447


		2015 Vol. 25 (05): 447-449 [Abstract] ( 403 ) [HTML 1KB] [ PDF 1579KB] ( 1552 )

	450


		2015 Vol. 25 (05): 450-452 [Abstract] ( 376 ) [HTML 1KB] [ PDF 717KB] ( 1036 )

	453


		2015 Vol. 25 (05): 453-454 [Abstract] ( 387 ) [HTML 1KB] [ PDF 718KB] ( 1458 )

	455


		2015 Vol. 25 (05): 455-458 [Abstract] ( 447 ) [HTML 1KB] [ PDF 963KB] ( 1602 )

江苏大学学报:医学版

　

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