Objective： To analyse the clinicopathological features of patients with papillary thyroid carcinoma (PTC) combined with breast cancer and to explore the possible relationship between these two cancers. Methods： A total of 99 patients with PTC combined with breast cancer (combined cancer group) who were admitted to the Thyroid Surgery Department of the First Affiliated Hospital of Zhengzhou University from December 2016 to December 2021 were selected, and 99 patients with PTC without breast nodule (simple cancer group) who were treated during the same period were selected. The general characteristics, PTC pathological characteristics, thyroid hormone, antigen and antibody levels were compared between the two groups. According to the order of diagnosis and the interval time, the patients with PTC combined with breast cancer were divided into breast-thyroid group (diagnosed with PTC after breast cancer), thyroid-breast group (diagnosed with breast cancer after PTC) and simultaneous group (the interval between the diagnosis of two cancers did not exceed 6 months). The age at diagnosis of PTC and breast cancer, the interval between diagnosis of two cancers, the lymph node metastasis of PTC and pathological characteristics of breast cancer were compared among the three groups. Results： Compared with the simple cancer group, the tumor in the combined cancer group was smaller in maximum diameter, more inclined to microcarcinoma, and less likely to invade the capsule and surrounding tissues; the age at the time of diagnosis of PTC was significantly older, most of them were in menopausal state; the level of serum free tetraiodothyronine (FT4) was also significantly decreased, while the level of thyroglobulin (Tg), thyroid peroxidase antibody (TPOAb) and thyrotropin receptor antibody (TRAb) were significantly increased (all P<0.05). Compared with the thyroid-breast group, the interval between diagnosis of two cancers in the breast-thyroid group was significantly shorter (P<0.05). Compared with the simultaneous group, the rate of cervical lymph node metastasis in the breast-thyroid group was significantly higher (P<0.05). Conclusion： Thyroid tumors in patients with PTC combined with breast cancer were smaller in maximum diameter, and some patients developed rapidly and were prone to skip metastasis; PTC patients with high expression level of Tg, TPOAb and TRAb had an increased risk of breast cancer.
［Key words］papillary thyroid carcinoma; breast cancer; thyroid hormone; thyroglobulin; thyroid associated antibody; lymph node metastasis; microcarcinoma

目的: 分析无充气腋窝入路腔镜甲状腺手术的临床效果。方法: 回顾性分析2021年1月至12月苏州大学附属第一医院收治的100例行无充气腋窝入路腔镜甲状腺手术患者的临床资料，包括手术方式、手术时间、术中出血量、术后总引流量、术后拔管时间、术后并发症，术后住院时间、常规病理结果以及手术效果满意度。结果: 100例患者均顺利完成手术，行患侧腺叶切除+峡部切除+中央区淋巴结清扫术69例，行患侧甲状腺肿块切除或甲状腺部分切除术31例，其中1例损伤喉返神经，术中行神经吻合；手术时间(102±32)min；术中出血量(15±5)mL；病灶最大直径(15±11)mm；甲状腺乳头状癌30例，甲状腺微小乳头状癌39例，甲状腺滤泡性肿瘤2例，结节性甲状腺肿19例，甲状腺腺瘤10例；中央区淋巴结清扫69例，其中40例无淋巴结转移，29例有淋巴结转移；术后引流管总引流量(170±97) mL，术后拔管时间(3±1)d；术后住院时间(2±1)d；手术满意度(8.67±1.22)分。结论:无充气腋窝入路腔镜甲状腺手术切口隐蔽、术中出血少、手术操作相对安全、术后不适症状少、美容效果好以及患者接受度高，严格把握手术适应证后值得在临床上推广。

甲状腺癌是临床常见的恶性肿瘤之一，近年来，其发病率逐年上升；超重和肥胖人口占比也逐年升高，与甲状腺癌有高度同步的流行病学特征，由此提示肥胖和甲状腺癌可能存在联系。本文针对甲状腺癌的发生发展与肥胖引起的代谢异常，如胰岛素抵抗、脂肪因子和激素紊乱等之间存在的相关性以及可能的作用机制作一综述。

乳腺癌是全球女性最常见的恶性肿瘤，尽管其治疗已取得进展，但仍然是女性癌症死亡的主要原因。非编码RNA(noncoding RNA, ncRNA)在乳腺癌的发生发展中起关键作用，但是不同ncRNA之间存在的作用机制尚不清楚。近来，RNA研究领域新提出的概念是“竞争性内源性RNA(competing endogeous RNA, ceRNA)”，即不同RNA之间存在相互调节作用，包括长链非编码RNA（long noncoding RNA，LncRNA）、微小RNA、转录假基因和环状RNA。研究表明，这些RNA之间的作用失调在促进或抑制乳腺癌发生发展方面具有重要作用。本文针对ceRNA网络调控轴在乳腺癌中的研究进展作一综述。

乳腺癌是发生在乳腺腺上皮组织的恶性肿瘤，同时也是全球女性中常见的癌症类型，其发病率和病死率逐年增高。随着细胞生物学的发展，干细胞逐渐被用于各种癌症如乳腺癌、胰腺癌和前列腺癌等的研究及治疗。间充质干细胞(mesenchymal stem cells，MSCs)因其具有分化潜能、免疫原性低、肿瘤趋向性及分泌细胞因子等特点，而被广泛用于癌症治疗。多项研究表明，MSCs对乳腺癌细胞增殖、迁移和侵袭等具有不同程度的影响。因此，本文针对脂肪、脐带、胎盘和骨髓来源的MSCs对乳腺癌细胞的生物学影响及MSCs在乳腺癌治疗策略方面的主要研究进展作一综述。