血小板内皮细胞黏附分子1和平滑肌肌动蛋白对瘢痕疙瘩综合治疗预后的影响

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Abstract Objective： To explore the effect of the expression levels of platelet endothelial cell adhesion molecule-1 (PECAM-1) and smooth muscle actin (SMA) in the blood vessels of keloid on the prognosis of comprehensive treatment of keloid. Methods： From August 2020 to June 2022, a total of 61 patients with keloids diagnosed and treated in the Department of Dermatology, Affiliated Hospital of Jiangsu University were retrospectively analyzed, with a total of 69 keloids. All patients received comprehensive treatment of surgical resection and 90Sr isotope application. Immunohistochemical staining was used to detect the expression levels of PECAM-1 and SMA in blood vessels of surgically resected keloid specimens. All patients were followed up for 6 months by telephone and outpatient service. Results： A total of 19 (27.5%) keloids recurred within 6 months, and 11 (15.9%) had adverse reactions after 90Sr isotope application. The high expression rates of PECAM-1 and SMA in the recurrence group were higher than those in the non-relapse group (χ2=7.496, P=0.006; χ2=5.197, P=0.023); the incidence of adverse reactions after treatment had no significant association with the expression levels of PECAM-1 and SMA (χ2=0.172, P=0.935; χ2=1.110, P=0.484). Conclusion： The expression levels of PECAM-1 and SMA in keloid blood vessels were negatively correlated with the prognosis of comprehensive treatment, and they may be potential indicators for judging the prognosis of keloid.

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Received: 14 April 2023

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	Articles by authors
	YANG Yifei1
	2
	XU hui1
	2
	LONG Weiguo3
	LI Yumei1
	2

Cite this article:

YANG Yifei1,2,XU hui1等. Effect of PECAM-1 and SMA on the prognosis of keloid after comprehensive treatment[J]. Journal of Jiangsu University(Medicine Edition), 2024, 24(01): 57-60.

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2024/V24/I01/57

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