|
|
ultrasound parameters in the central region of thyroid nodules in the differential diagnosis of benign and malignant nodules |
ZHOU Chao, XU Xinyan, NI Qingfeng, SHEN Bo, WU Xiaoman, HUANG Yan, ZHU Zheng |
ZHOU Chao, XU Xinyan, NI Qingfeng, SHEN Bo, WU Xiaoman, HUANG Yan, ZHU Zheng |
|
|
Guide |
|
Abstract Objective:To investigate the clinical significance of combined shear wave elastography (SWE) parameters and quantitative analysis parameters of contrastenhanced ultrasound (CEUS) in the differential diagnosis of benign and malignant thyroid nodules. Methods: A total of 71 patients with malignant thyroid nodules and 65 patients with benign thyroid nodules who underwent auxiliary diagnosis in the ultrasound department of Taicang First People′s Hospital from January 2019 to January 2021 were selected. All patients underwent SWE and CEUS. The differences in twodimensional ultrasonographic appearance of benign and malignant nodules, SWE and CEUS parameters in the central area were analyzed.Logistic regression model was used to screen the parameters for judging malignant nodules in SWE and CEUS, the receiver operator characteristic (ROC) curve was drawn using pathological diagnosis as the gold standard, and the area under the curve (AUC) was calculated,and the predictive value of each factor and combined diagnosis of malignant thyroid nodules was analyzed.Results: The twodimensional ultrasonography of benign and malignant thyroid nodules had significant differences in morphology, margin, aspect ratio and microcalcification, and there were differences in central area Emin, Emean, Emax, Peak and AUCt of benign and malignant thyroid nodules (P<0.001). Logistic regression results showed that Emax and Peak entered the regression equation. The ROC curve results showed that among the SWE parameters, the area under the Emax curve was the largest and had the highest diagnostic performance, while Peak was the best diagnostic index in the CEUS parameters, and the AUC value of Emax and Peak in the diagnosis of malignant thyroid nodules was 0.837, which was greater than that of either SWE or CEUS alone.Conclusion:The diagnostic value of Emax and Peak in the central area of thyroid nodules is higher than that of other single parameters, and it has certain guiding significance for the noninvasive examination and diagnosis of thyroid nodules in clinical practice.
|
Received: 10 March 2022
|
Fund: |
|
|
|
[1]赵欣,旦增贡色,张志斌,等. 甲状腺结节硬度对粗、细针穿刺活检标本满意度的影响[J]. 临床耳鼻咽喉头颈外科杂志, 2020, 34(11): 1011-1013.
[2]张强,张仑,王旭东,等. 甲状腺超声智能诊断的现状及研究进展[J]. 中国肿瘤临床, 2021, 48(4): 192-196.
[3]王晨琛,詹维伟.甲状腺结节壁结构的超声评估指标研究进展[J].中国医学影像学杂志, 2018, 26(12): 949-951,956.
[4]杨倩,郝晶,刘周,等. 基于甲状腺专用表面线圈的甲状腺磁共振检查和超声检查的对比研究[J]. 临床放射学杂志, 2021, 40(10): 1874-1878.
[5]余幼林,沈雄山,胡超华,等. 基于血浆循环游离DNA与甲状腺结节超声特征构建甲状腺癌诊断模型及其验证[J]. 中国普通外科杂志, 2021, 30(8): 955-963.
[6]Alexander LF,Patel NJ,Caserta MP,et al. Thyroid ultrasound:diffuse and nodular disease[J]. Radiol Clin North Am, 2020, 58(6): 1041-1057.
[7]王冰,郗洪庆,万政,等. 单中心9662例甲状腺癌流行病学特征及临床病理特征分析[J].中华内分泌外科杂志, 2021, 15(4): 342-347.
[8]张歆,薛玉,沈楚,等.甲状腺微小乳头状癌彩超征象危险因素的Logistic回归分析[J].江苏大学学报(医学版), 2013, 23(1): 75-77.
[9]蒋丽萍,周爱云,吴开志. SWE及CEUS对腮腺腺瘤和恶性肿瘤的鉴别诊断价值[J]. 中国超声医学杂志, 2020, 36(7): 603-605.
[10]陈佳,黎玲. SWE参数弹性模量值在乳腺癌发生腋窝淋巴结转移诊断中的价值[J]. 影像科学与光化学, 2021, 39(4): 533-537.
[11]李响,程慧芳,闫虹,等. 常规超声联合SDetect技术对乳腺病灶的诊断价值[J]. 中国超声医学杂志, 2019, 35(3): 225-228.
[12]赵恒达,王怡. 甲状腺良恶性结节SWE技术参数与超声造影参数的相关性及联合诊断价值分析[J]. 影像科学与光化学, 2021, 39(4): 526-532.
[13]Huang S,Cai W,Han S,et al. Differences in the dielectric properties of various benign and malignant thyroid nodules[J]. Med Phys, 2021, 48(2): 760-769.
[14]Azizi G,Keller JM,Mayo ML,et al. Shear wave elastography and AfirmaTMgene expression classifier in thyroid nodules with indeterminate cytology: A comparison study[J].Endocrine, 2018, 59(3): 573-584.
[15]马姣姣,孙脉,田艳,等.超声造影定量参数在甲状腺良恶性结节鉴别诊断中的价值[J].中国医学科学院学报, 2020, 42(1): 80-85.
|
|
|
|