Abstract：Objective: To observe the potential protective effects of mildronate (THP) on the lung tissue in acute lung injury (ALI) in mice. Methods: The experimental objects were randomly divided into normal control, lipopolysaccharides alone, and lipopolysaccharides+THP groups. Mice in lipopolysaccharides +THP group were intraabdominal preinjection with THP at dosage of 100 mg/kg. ALI models were duplicated by means of intratracheal instillation of lipopolysaccharides. The antioxidant ability was analyzed by malondialdehyde(MDA), total superoxide dismutase(T-SOD) activity, and myeloperoxidase (MPO) assays. The structure of lung was examined by light microscope. Results: Compared with lipopolysaccharides alone group, MDA and MPO were decreased significantly(P<0.05) in normal control group and THP+ lipopolysaccharides group, while T-SOD activity was increased. Meanwhile, pretreatment with THP significantly improved the lung pathologic change. Conclusion: THP can protect the lung tissue from damage by lipopolysaccharides.
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2012, Vol. 22 
