Abstract：Objective: To observe the regulation of rhein on the hyperlipidemia mouse model induced by high fat diet. Methods: The hyperlipidemia mouse models induced by high fat diet were performed successfully and were randomly divided into rhein group (6 mice), model group (6 mice) and control group (6 mice) were normal C57BL/6 mice. After treatment of 8 weeks, growth rate in body weight, food intake, liver fat content, serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum creatinine (SCr) were observed. Results: The foodintake in model group and rhein group decreased than those in control group (P<0.01), while there was no significant difference between model group and rhein group (P>0.05). At the end of the experiment, the average weight growth rate in control group was 1.79%, while it was 10.69% in model group and 6.23% in rhubarb group. The average weight growth rate in rhein group was significantly lower than that in model group (P<0.01). The liver fat content is 2.71% in control group, 16.49% in model group, while it was 8.36% in rhubarb group; the liver fat content was significantly lower than that in model group (P<0.01). After treatment, the levels of AST, ALT, and SCr in three groups were no significant differences (P>0.05). Conclusion: Rhein have the function of inhibiting fat deposition in the liver, and the toxic side effects were very low.
2012, Vol. 22 
