Abstract：[Abstract]Objective: To investigate the frequency and clinical significance of myeloidderived suppressor cells(MDSC) in peripheral blood and tumor foci of the patients with cervical cancer. Methods: Flow cytometry was used to evaluate the proportion of MDSC in the blood of 17 patients with cervical cancer pretherapy and 20 healthy people. The proportions of MDSC in the tissue cell suspension were evaluated in 17 patients with cervical cancer and 15 healthy cervical tissues. Results: Compared with healthy volunteers, the proportions of circulating MDSC from cervical cancer were significantly higher(P＜0.01); and the MDSC in peripheral blood mainly consists of CD15 + granulocyte subgroup. The proportions of tissue cell suspension CD45+ cell from cervical cancer were significantly higher, compared with normal tissue cell suspension(P＜0.05)； but in tissue cell suspension CD33+cell was not found. The proportion of MDSC was positively correlated with the frequency of value of squamous cell carcinoma antigen in peripheral blood of patients with cervical cancer (r=0.715 4, P＜0.05). Conclusion: Granulocyte subgroup MDSC in the peripheral blood of patients with cervical cancer may be associated with the development of cervical cancer.
收稿日期: 2015-12-09
引用本文:
杨佩芳1， 周敏1， 何瑶1， 张译心1， 焦志军2. 宫颈癌患者外周血和宫颈组织中髓源性抑制细胞的检测及意义[J]. 江苏大学学报:医学版, 2016, 26(02): 172-175.
YANG Pei-fang1, ZHOU Min1, HE Yao1, ZHANG Yi-xin1, JIAO Zhi-jun2. Measurement and significance of myeloid-derived suppressor cells in peripheral blood and tumor tissue of patients with cervical cancer. Journal of Jiangsu University(Medicine Edition), 2016, 26(02): 172-175.
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