Association between neck circumference, insulin resistance and highly sensitive C-reactive protein in newly diagnosed type 2 diabetes patients with metabolic syndrome
QIAN Wei-yun,YU Shu-qin, ZHU Tian-yi, TANG Bing-qian, SUN Wen-jun, HU Hao,YE Jing-jing, WANG Dong, WANG Ji-fang, YANG Ling, YUAN Guo-yue
（Department of Endocrinology, Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001, China)
Abstract：Objective: To investigate neck circumferences in patients with type 2 diabetes mellitus (T2DM) with metabolic syndrome(MS), and to study the association between neck circumference, insulin resistance and highly sensitive C-reactive protein. Methods: A total of 165 subjects were enrolled in the study, including 55 healthy subjects and 110 patients with newlydiagnosed type 2 diabetes(T2DM) which were divided into T2DM group and T2DM with MS group. Oral glucose tolerance test(OGTT) and insulin releasing test were performed in all subjects, meanwhile, neck circumference, blood lipid, hs-CRP and other items were measured. Results: Compared with control group and T2DM group, the neck circumference was increased in MS group[(38.47±3.68) vs (35.17±3.09)cm, (38.47±3.68) vs (36.86±2.92)cm, P<0.05 or P<0.01, respectively]. The serum hs-CRP in MS group was higher than in normal control group and T2DM group[2.77(1.19~5.55) vs 0.40(0.18~0.98)mg/L, 2.77(1.19~5.55) vs 1.74(0.81~5.33)mg/L, P<0.01, respectively]. Subjects in the upper neck circumference fertile had higher levels of BMI, WC, WHR, FINS, PSI, TG, HOMAIR and hsCRP, while lower levels of HDLC when compared to subjects in the middle or lower neck circumference fertile(P<0.05 or P<0.01). The neck circumference was positively correlated with BMI, WC, WHR, DBP, FPG, 2hPG, FINS, PSI, TG， LDL-C, HOMAIR and hsCRP, while negatively correlated with HDL-C(P<0.05 or P<0.01). Logistic regression analysis showed that neck circumference, WC and TG were independent risk factors for T2DM with MS, while HDL-C was the protective one(P<0.01). Conclusion: Newlydiagnosed type 2 diabetes mellitus patients with MS tend to have bigger neck circumference, the neck circumference was associated with insulin resistance and hs-CRP. The neck circumference was the risk factor for T2DM with MS.
2014, Vol. 24 
