Abstract：Objective To explore the diagnostic value of Peguero-Lo Presti index on heart failure with preserved ejection fraction (HFpEF). Methods We selected patients with clinical symptoms of heart failure (HF) who had been hospitalized in the Department of Cardiology of Provincial Clinical Medical College, Fujian Medical University; their clinical data were complete, including ECGs, cardiac ultrasound, biochemistry, and NT-proBNP. Based on the HFA-PEFF score standard recommended by the Guidelines for the diagnosis and treatment of acute and chronic HF, 120 patients were enrolled in the HFpEF group (60 males and 60 females) while 100 cases without HF were divided into the control group (56 males and 44 females). The baseline data characteristics were compared between the two groups. Peguero-Lo Presti index, Cornell product index, and RomhiltEstes score were separately calculated and analyzed in the standard 12lead ECGs. We compared the area under the ROC curve, sensitivity and specificity of the above three indicators for diagnosing HFpEF. Results Compared with the control group, there was no statistically significant difference in the baseline data such as sex, age, diabetes proportion, coronary heart disease, highdensity lipoprotein cholesterol, and serum creatinine in the HFpEF group (P>0.05); the proportion of hypertension, lowdensity lipoprotein cholesterol and hyperuricemia increased (P<0.05). In the male subgroup, the area under the ROC curve of the Peguero-Lo Presti index was 0.84 (0.76, 0.90), which was higher than that of the Cornell product index \[0.70 (0.61, 0.78)\] and that of the Romhilt-Estes score[0.62 (0.53, 0.71)\ (all P<0.05). The sensitivity of the PegueroLo Presti index was 6667%, which was higher than that of the Romhilt-Estes score (36.57%) and that of the Cornell product index (48.33%), with statistically significant differences (all P<0.05) while the difference of specificity was not statistically significant. In the female subgroup, the area under the ROC curve of the Peguero-Lo Presti index was 0.77 (0.69, 0.85), which was higher than that of the Cornell product index [0.68 (0.58, 0.77)] and that of the Romhilt-Estes score [0.57(0.47, 0.66)， all P<0.05］. The sensitivity of the Peguero-Lo Presti index was 68.33%, which was higher than that of the Romhilt-Estes score (26.67%), with statistically significant difference (P<0.01) while the difference of specificity was not statistically significant. Conclusion The Peguero-Lo Presti index of ECG has high sensitivity and specificity for diagnosing HFpEF. The examination method is convenient, and could be used as an auxiliary diagnosis and screening index for HFpEF clinically.
陈乐昀，游濠乐，郑炜平. Peguero-Lo Presti指数对射血分数保留型心力衰竭的诊断价值[J]. 实用心电学杂志, 2024, 33(2): 122-127.
陈乐昀，游濠乐，郑炜平. Diagnostic value of Peguero-Lo Presti index on heart failure with preserved ejection fraction. JOURNAL OF PRACTICAL ELECTROCARDIOLOGY, 2024, 33(2): 122-127.
