To explore the effects of rotation irrigation mode with saline-freshwater on tomato growth and development, soil nutrients and salt ions characteristics in arid and semiarid agricultural areas, ″fresh-fresh-saline-saline″(T1), ″saline-saline-fresh-fresh″(T2), ″fresh-saline-saline-fresh″(T3), ″fresh-fresh-saline-saline″(T4), ″fresh-saline-fresh-saline″(T5), ″saline-fresh-saline-fresh″(T6)six irrigation methods were set up during the key growth period of tomato, and a two-year field experiment was carried out. The results indicate that the saline-freshwater rotation irrigation me-thod can save 30.0%-66.7% of freshwater compared with traditional freshwater continuous irrigation during the tomato growth period. The ″fresh-fresh-saline-saline″ rotation irrigation method is more conducive to reducing soil nitrogen loss in the taproot layer of tomatoes.The soil salt cation and anion contents increase with the increase of saline water irrigation amount. Under the lower limit of soil matrix potential control of -25 kPa, the rotation irrigation of saline-freshwater during the tomato growth period results in salt accumulation in the surface 40 cm inside and outside the film as well as(40,100] cm inside the film, and the salt content of the surface 40 cm inside the film for the rotation irrigation modes increases by 7.8%-67.2% compared with the traditional freshwater irrigation. Compared with traditional freshwater irrigation, saline-freshwater rotation irrigation significantly reduces the weight of single tomato fruit, with the tomato yields decreasing by 1.9%-18.3%, while the fruit lycopene content and total sugar content increase by 6.2%-18.5% and 4.8%-15.2%, respectively. Dramatically, the ″fresh-fresh-saline-saline″ mode achieves the maximum tomato yield, highest lycopene content and maximum total sugar content. Therefore, it is suggested that in the Hetao Irrigation District of Inner Mongolia, the best rotation irrigation method of saline-freshwater for tomatoes under film drip irrigation is ″irrigation with Yellow River water from the seedling stage to flowering stage″ and ″irrigation with shallow groundwater from fruit setting stage to fruit expansion stage″.