Abstract: In order to develop high head and high efficiency deep-well centrifugal pump, 100QJ10 deep-well centrifugal pump was taken as an example. The orthogonal experiment of L9(34), which contains factors with three levels of outlet angle, outlet width, outside diameter of impeller back shroud, etc, was performed to design nine types of impellers. According to standard k-ε model, SIMPLEC algorithm, second-order upwind scheme which were deduced from Fluent, the whole flow field of new type two-stage deep-well centrifugal pump at the operating point was numerically simulated. Nine groups of efficiency and head for design scheme were obtained at rated condition. The effects of geometrical parameters on efficiency and head were discussed by Latin square test method. The primary and secondary factors of the design parameters were acquired by variance analysis. According to the test results, an optimum program for further design was proposed. The test of pump prototype shows that the efficiency of optimal design model pump can reach 58.41% with singlestage head of 5.2 m at rated condition. The improved efficiency and head can meet the design requirements.