Abstract:The prestressing loss calculated by the current code of China can′t fit actual engineering ideally. To solve the problem,with the considerations of construction factor, materials performance and environment condition, the response surface method was employed for uncertainty analysis of prestressing loss of large span continuous rigid frame bridge. Taking a continuous rigid frame bridge as project background, eight main structure parameters and Bucher design method were adopted to conduct the experimental design with three levels. The response surface models without influence of cross-terms were established to express the complex implicit relationship between prestressing loss and random parameters by approximate explicit functions. The significance test and the accuracy test on response surface models were carried out using F test and corrected determination coefficient. The significance analysis of basis function based on stepwise regression and the sensitivity analysis of parameters were conducted by the Spearman rank correlation coefficient. The prediction of prestressing loss in the sense of probability was realized by Monte Carlo sampling analysis.