Abstract: CHEMKINPRO chemical kinetic software was applied to construct a simplified kinetic mechanism with 101 components and 692 primitive reactions for methanol/FischerTropsch(F-T) diesel characterization fuelcombustion. The combustion conditions of methanol/F-T diesel fuel during premixed combustion in diesel engines were simulated by the reflected excitation tube model, and the combustion characteristics of methanol/F-T diesel fuel under different initial premixed combustion conditions and different methanol blending ratios were investigated. The simulation results show that with the increasing of initial temperature and initial pressure, each combustion reaction rate is accelerated. The increasing of initial pressure can promote the complete combustion of blended fuel, while the increasing of initial temperature can inhibit the complete combustion of blended fuel. The increasing of equivalence ratio can inhibit the formation of oxygens and promote the formation of hydrogen radicals, which plays an inhibiting role on the combustion reaction of blended fuel. With the increasing of methanol blending ratio, the rate of F-T diesel consumption and the rate of intermediate radical generation are decreased, which can inhibit the combustion of blended fuels with decreased consumption sensitivity of hydro radical and decreased generation sensitivities of hydroxy and oxy radical.