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| Association of serum GLP-1 with bone mineral density, bone turnover markers and osteoporotic fractures in the postmenopausal women |
| ZHANG Qinglong 1,2, ZHANG Keqin 1,3, LI Ran 1,3 |
| 1. Tongji University School of Medicine, Shanghai 200438； 2. Department of General Practice, Chongming Changxing Community Health Center, Shanghai 201913； 3. Department of Endocrinology, Tongji Hospital, Tongji University, Shanghai 200065, China |
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Abstract Objective： To investigate the relationship between serum glucagon-like peptide-1 (GLP-1) level and bone mineral density, bone turnover markers and osteoporotic fracture in postmenopausal women. Methods： From January 2020 to December 2021, a total of 206 postmenopausal women who received physical examination were enrolled. According to the results of dual-energy X-ray absorptiometry in patients with lumbar spine and left hip bone density, they were divided into osteoporosis group (90 cases) and non-osteoporosis group (116 cases).The serum GLP-1, type Ⅰ procollagen N-terminal propeptide (PINP), osteocalcin (OC), β-type Ⅰ collagen C-terminal peptide (β-CTX), specific bone alkaline phosphatase (BALP) and tartrate-resistant acid phosphatase (TRACP) levels were determined. The probability of osteoporotic fracture was assessed by the Osteoporotic Fracture Risk Prediction Simple Tool (FRAX). The general information between the two groups (age, menopausal age, menopausal years, height, weight, BMI, waist circumference, hip circumference, waist/hip and bone mineral density of each part), differences in serum GLP-1 and bone turnover markers were compared and the correlation between serum GLP-1 level and bone turnover markers, the probability of osteoporotic fracture in postmenopausal women was analyzed. Binary logistic regression analysis was performed on the influencing factors of osteoporosis in postmenopausal women. Results： Compared with the non-osteoporosis group, the number of menopausal years of the patients in the osteoporosis group increased significantly, and the weight, waist circumference, hip circumference, BMI and bone mineral density of all parts decreased significantly. There was no statistical difference between the two groups in age, menopausal age, height, waist/hip.The serum GLP-1 level in osteoporosis group was significantly lower than that in non-osteoporosis group, the levels of PINP and OC were significantly higher, TRACP, BALP, β-CTX has no statistical difference between the two groups.GLP-1 level was not correlated with bone turnover markers, but positively correlated with bone mineral density of L1-4 sum, femoral neck and left hip sum. GLP-1 level was negatively correlated with major osteoporotic fracture probability (MOFP) and hip osteoporotic fracture probability (HOFP). BMI and GLP-1 levels can be considered as independent protective factors for postmenopausal osteoporosis, and years of menopause and OC levels can be considered as independent risk factors for osteoporosis. Conclusion： Serum GLP-1 levels were significantly decreased in postmenopausal women with osteoporosis. GLP-1 levels can be considered as an independent protective factor for postmenopausal osteoporosis. GLP-1 levels are associated with the risk of osteoporotic fractures in the postmenopausal women.
［Key words］glucagon-like peptide 1; postmenopausal osteoporosis; bone turnover marker; bone mineral density; osteoporotic fracture
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