卵巢癌患者外周血Treg细胞和Th1、Th2细胞因子的变化及其与临床病理特征的关系

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Abstract Objective: To investigate the percentage of Treg cells in T cells in peripheral blood of ovarian cancer patients and the expression levels of Th1 cells and Th2 cytokines, and analyze the relationship between the above indicators and the clinicopathological characteristics of ovarian cancer. Methods: A total of 60 patients were chosen as malignant group with ovarian cancer who had been treated by laparoscopic ovarian cancer radical surgery and pathologically confirmed. In addition, 60 cases of benign ovarian diseases(benign group) and 60 cases of healthy women(control group) admitted by the hospital during the same period were enrolled. Changes of Treg cells and Th1 and Th2 cytokines in peripheral blood of each group were determined. The levels of Treg cells and Th1 and Th2 cytokines in different clinical stages and histological type were analyzed. Results: Between the control group and the benign group, there was no significant difference in the levels of cytokines IL2, IL4, IL10, INFγ, TNFα and the proportion of Treg cells in peripheral blood CD4+T cells(P>0.05). Compared with the control group and the benign group, the level of IL2 in the malignant group was significantly decreased(P<0.05), while the levels of IL2, INFγ and TNFα in the malignant group were lower than those in the control group and the benign group(P<0.05)， while the levels of IL4, IL10 and the percentage of Treg cells were higher than those in the control group and the benign group(P<0.05). With the increasing of clinical stage of ovarian cancer, the INFγ, TNFα levels gradually decreased (P<0.05), but the magnitude of IL2 changes did not reach statistical significance. The expression levels of IL4 and IL10 gradually increased, and the proportion of Treg cells also increased(P<0.05). Compared with mucinous property type and other histological type, IL4, IL10 and TNFα levels of serious ovarian cancer were significantly increased(P<0.05). Conclusion: The levels of both Th1 and Th2 cell cytokines in peripheral blood of patients with ovarian cancer at different clinical pathology and clinical stage is unbalanced. With the progression of clinical stage, the percentage of Treg cells in patients with malignant ovarian cancer is increased.

Received: 12 September 2018

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2019/V29/I02/153

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