|
|
Effects of ultralowdose naloxone on analgesia of
dezocine in rats with incisional pain
|
BAO Yang1, JIAO Ying-fu2, YU Wei-feng2 |
(1. Department of Anesthesiology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai 201800; 2. Department of Anesthesiology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200127, China)
|
|
|
Abstract Objective: To investigate the effects of ultralowdose naloxone on analgesia of dezocine in rats with incisional pain. Methods: Models of postoperative incision pain (Brennan′s method) in 24 male SD rats were eatablished. Rats were randomly divided into 4 groups(n=6, each group) receiving normal saline, ultralow dose naloxone(1 ng/kg), dezocine(1 mg/kg) and dezocine(1 mg/kg)+naloxone(1 ng/kg) respectively via the tail vein. PWT values in ipsilateral side of hind paws were measured 1 d before surgery, 2 h after surgery, and 1 d, 3 d, 5 d, 7 d after surgery. Results: There were no statistical significance in the PWT values at 1 d, 3 d, 5 d and 7 d among the four groups(P>0.05). Within each group, compared with baseline, PWT values were significantly decreased on 1 d, and 3 d after surgery, while no difference on 5 d, 7d after surgery(P<0.01). There was no difference of PWT values between naloxone group and normal saline group(P>0.05) 2 h after the incision. Dezocine group and dezocine+naloxone group were shown to have significantly higher PWT values than the normal saline group(P<0.01). Dezocine+naloxone group was shown to have significantly higher PWT values than dezocine group (P<0.01). Conclusion: Though ultralow dose of naloxone has no analgesic effect when used alone, it could enhance the analgesic efficacy of dezocine.
|
Received: 25 October 2018
|
|
|
|
[1]Sun Q, Zhou W, Wu B, et al. Dezocine: a novel drug to prevent fentanylinduced cough during general anesthesia induction?\[J\]. J Anesth, 2012, 26(3): 470.[2]Bruijnzeel AW. κOpioid receptor signaling and brain reward function\[J\]. Brain Res Rev, 2009, 62(1): 127-146.[3]Movafegh A, Shoeibi G, Ansari M, et al. Naloxone infusion and posthysterectomy morphine consumption: a doubleblind, placebocontrolled study\[J\]. Acta Anaesthesiol Scand, 2012, 56(10): 1241-1249.[4]Imasogie NN, Singh S, Watson JT, et al. Ultra lowdose naloxone and tramadol/acetaminophen in elderly patients undergoing joint replacement surgery: a pilot study\[J\]. Pain Res Manag, 2009, 14(2): 103-108.[5]Brennan TJ, Vandermeulen EP, Gebhart GF. Characterization of a rat model of incisional pain\[J\]. Pain, 1996, 64(3): 493-501.[6]Crain SM, Shen KF. Antagonists of excitatory opioid receptor functions enhance morphine′s analgesic potency and attenuate opioid tolerance/dependence liability\[J\]. Pain, 2000, 84(2/3): 121-131.[7]Singh VP, Patil CS, Jain NK, et al. Paradoxical effects of an opioid antagonist naloxone on SSRIinduced analgesia and tolerance in mice\[J\]. Pharmacology, 2003, 69(3): 115-122.[8]Sadeghi M, Movafegh A, Nouralishahi B. The effect of an intravenous bolus of ultralow dose naloxone on intraoperative sedation, post operative pain intensity and morphine consumption in cesarean section patients under spinal anesthesia\[J\]. Res J Bio Sci, 2008, 3(10): 1223-1228.[9]徐建国, 罗爱伦, 吴新民, 等. 地佐辛术后镇痛专家建议\[J\]. 临床麻醉学杂志, 2013, 29(9): 921-922.[10]Liu R, Huang XP, Yeliseev A, et al. Novel molecular targets of dezocine and their clinical implications\[J\]. Anesthesiology, 2014, 120(3): 714-723. |
[1] |
WANG Juan, HAN Ming-Xiu, XIE Rong. [J]. Journal of Jiangsu University(Medicine Edition), 2013, 23(6): 523-. |
|
|
|
|