2型糖尿病患者外周血中性粒细胞/淋巴细胞比值与骨质疏松的关系

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (785 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract
\[Abstract\]Objective: To explore the relationship between the blood neutrophil lymphocyte ratio(NLR) and osteoporosis in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 364 T2DM patients were classified into normal bone mass group，osteopenia group and osteoporosis group according to the bone mineral density(BMD). We measured the whole blood cell count and leukocyte classification,than calculated the blood NLR. The prevalence of osteoporosis as well as the difference of NLR were observed among all the groups. The relationship of NLR to BMD was analyzed. Multiple Logistic regression analyses was used to identify the risk factors of osteoporosis. Results: The prevalence of osteoporosis was 18.5%(67 patients), female was 25.9% (46 patients) and male was 11.3% (21 patients), premenopausal women was 11.6%(10 patients)，postmenopausal women was 39.1% (36 patients).In male, premenopausal women and postmenopausal women, the NLR was significantly higher in osteoporosis group compared to normal bone mass group and osteopenia group (P<0.01 or P<0.05). In male, premenopausal women and postmenopausal women, NLR was negatively associated with BMD(r=-0.306，P＜0.01; r=-0.316，P＜0.01; r=-0.322，P＜0.01) respectively. Multiple Logistic regression analyses revealed that age, gender, BMI, NLR and duration of diabetes were independent risk factors of osteoporosis in T2DM(P<0.01 or P<0.05). Conclusion: Inflammation may play important role in osteoporosis, and depressing inflammation may be beneficial in reducing the occurrence of osteoporosis.

Received: 17 April 2017

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2017/V27/I5/437

［1］Schacter GI, Leslie WD. Diabetes and bone disease\[J\]. Endocrinol Metab Clin North Am, 2017, 46(1):63-85.
［2］Gibon E, Lu L, Goodman SB, et al. Aging, inflammation, stem cells, and bone healing\[J\]. Stem Cell Res Ther, 2016, 7:44.
［3］Loi F, Crdova LA, Pajarinen J, et al. Inflammation, fracture and bone repair\[J\]. Bone, 2016, 86:119-130.
［4］尹嘉品，彭永德．糖尿病与骨质疏松\[J\]．中华内分泌代谢杂志，2014，30(5)：449-452.
［5］Tolba MF, ElSerafi AT, Omar HA. Caffeic acid phenethyl ester protects against glucocorticoidinduced osteoporosis in vivo: Impact on oxidative stress and RANKL/OPG signals\[J\]. Toxicol Appl Pharmacol, 2017, 324:26-35.
［6］Lin TH, Pajarinen J, Lu L, et al. NFκB as a therapeutic target in inflammatoryassociated bone diseases\[J\]. Adv Protein Chem Struct Biol, 2017, 107:117-154.
［7］Linv IC, Yamashita S, Murata M, et al. Equol suppresses inflammatory response and bone erosion due to rheumatoid arthritis in mice\[J\]. J Nutr Biochem, 2016, 32:101-106.
［8］Croft M, Siegel RM. Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases\[J\]. Nat Rev Rheumatol, 2017, 13(4):217-233.
［9］Vakili H, Shirazi M, Charkhkar M, et al. Correlation of platelettolymphocyte ratio and neutrophiltolymphocyte ratio with thrombolysis in myocardial infarction frame count in STsegment elevation myocardial infarction\[J\]. Eur J Clin Invest, 2017, 47(4):322-327.
［10］Nam SH, Kang SG, Song SW. The neutrophillymphocyte ratio is associated with coronary artery calcification in asymptomatic Korean males: A crosssectional study\[J\]. Biomed Res Int, 2017, 2017:1989417.
［11］Takeuchi H, Kawanaka H, Fukuyama S, et al. Comparison of the prognostic values of preoperative inflammationbased parameters in patients with breast cancer\[J\]. PLoS One, 2017, 12(5):e0177137.
［12］Li H, Lu X, Xiong R, et al. High neutrophiltolymphocyte ratio predicts cardiovascular mortality in chronic hemodialysis patients \[J\]. Mediators Inflamm, 2017, 2017:9327136.
［13］Lu M, Yin N, Liu W, et al. Curcumin ameliorates diabetic nephropathy by suppressing NLRP3 inflammasome signaling \[J\]. Biomed Res Int, 2017, 2017:1516985.
［14］Huang C, Li S. Association of blood neutrophil lymphocyte ratio in the patients with postmenopausal osteoporosis \[J\]. Pak J Med Sci, 2016, 32(3):762-765.
［15］ztürk ZA, Yesil Y, Kuyumcu ME, et al. Inverse relationship between neutrophil lymphocyte ratio(NLR) and bone mineral density (BMD) in elderly people\[J\]. Arch Gerontol Geriatr, 2013, 57(1):81-85.
［16］王宁, 秦明照, 崔晶