巨细胞病毒感染对异体造血干细胞移植急性髓系白血病患者外周血CD8+/CD4+T细胞分布的影响

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Abstract Objective: To analyze the distribution of peripheral lymphocyte subsets of acute myeloid leukemia (AML) patients, who went through allogeneic hematopoietic stem cell transplantation (alloHSCT), and to investigate the relationship among cytomegalovirus (CMV) viremia, immune status and prognosis. Methods: We recruited 65 AML patients who had received alloHSCT. According to CMV infection status after transplantation, they were divided into CMV(+) (n=38) and CMV(－)(n=27) groups. We respectively collected their peripheral blood samples in different timepoints to analyse the ratios of lymphocyte subgroups and virus loads. KaplanMeier method, Fisher’s exact test, and the Cox proportional hazards regression model were used for statistical analysis between CMV infection and prognosis. Results: Immediately after transplantation, CMV(+) group showed inverted CD8+/CD4+ T cells ratio. CMV negatively turned in peripheral blood within six months by ganciclovir administration for two months. Although CD8+/CD4+ T cells ratio fell back, it was still higher than that before transplantation. CD8+ T cells were generally upregulated in both groups but more prominent in CMV(+) group within three months after transplantation. Conclusion: Peripheral lymphocytes distribution of AML patients after alloHSCT was altered by CMV infection, leading to inverted CD8+/CD4+ T cells ratio. CD8+ T cell was upregulated within three months postsurgery. These CMV infection and resulted in immune activation might favor leukemia free survival.

Received: 17 October 2016

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2017/V27/I5/423

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