血清小而密低密度脂蛋白胆固醇和总抗氧化能力水平与脑梗死患者认知功能障碍的相关性分析

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Abstract Objective： To investigate the serum small dense low-density lipoprotein cholesterol (sdLDL-C) and total antioxidant capacity (T-AOC) in patients with cerebral infarction and its relationship with cognitive dysfunction. Methods： A total of 148 patients with cerebral infarction were selected and divided into non-impaired group (n=77) and impaired group (n=71) according to whether cognitive dysfunction occurred 7 days after onset. The levels of serum sdLDL-C and T-AOC in the two groups were determined by hydroperoxidase and colorimetry, respectively, and compared. The correlation between serum sdLDL-C, T-AOC and Montreal Cognitive Assessment (MoCA) score in patients with cerebral infarction was analyzed by Pearson correlation coefficient method. The risk factors of cognitive dysfunction in patients with cerebral infarction were analyzed by binary Logistic regression. Results： Compared with the non-impaired group, the serum sdLDL-C level in the impaired group was significantly increased (P<0.05), and the T-AOC level was greatly decreased (P<0.05). Correlation analysis showed that serum sdLDL-C level was negatively correlated with MoCA score (r=-0.516, P<0.05), while T-AOC level was positively correlated with MoCA score (r=0.446, P<0.05). Logistic regression analysis showed that hypertension, diabetes, disease severity, serum sdLDL-C and T-AOC were independent factors affecting the occurrence of cognitive dysfunction in patients with cerebral infarction (P<0.05). Conclusion： The level of serum sdLDL-C is increased and the level of T-AOC is decreased in patients with cerebral infarction, which are independent influencing factors for cognitive dysfunction in patients with cerebral infarction.

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Received: 10 January 2023

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	MA Juan
	HAO Chenguang
	HE Dan
	MA Jianhua

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MA Juan,HAO Chenguang,HE Dan等. Correlation analysis of serum levels of small dense low-density lipoprotein cholesterol and total antioxidant capacity with cognitive dysfunction in patients with cerebral infarction[J]. Journal of Jiangsu University(Medicine Edition), 2024, 34(02): 161-165,175.

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2024/V34/I02/161

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