抑郁症家族史阳性首发患者和健康者脑血流灌注的变化

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Abstract Objective: To investigate the brain perfusion in firstepisode depressive patients and healthy people with family history of depression by application of arterial spin labeling (ASL). Methods: Fifty firstepisode depressive patients（21 patients with family history of depression and 29 without family history of depression）and 52 healthy subjects (22 subjects with family history of depression and 30 without family history of depression ) underwent ASLMRI scanning.The preprocessing and statistical analysis of CBF perfusion maps were based on SPM12. Results: Compared with healthy subjects，firstepisode depressive patients without family history of depression displayed significantly reduced CBF in the left middle frontal gyrus, the left superior occipital gyrus, the left thalamus as well as the right caudate nucleus and increased CBF in the left cingulate gyrus, the right lenticular and the right hippocampus.In contrast, firstepisode depressive patients with family history of depression had significant reduced CBF in the left middle frontal gyrus, the superior occipital gyrus and the right amygdala. Compared with patients without family history of depression, patients with family history had reduced CBF in the right amygdala and the left insula. Moreover, compared with healthy subjects without family history, healthy subjects with family history showed reduced CBF in the right amygdala. Conclusion: The brain perfusion changed in firstepisode depressive patients and healthy subjects with family history of depression, decline of CBF in the right amygdala was most remarkable.

Received: 02 April 2019

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	Articles by authors
	ZHANG Ning-ning1
	SHENG Liang-ju2
	XU Yu-hao3
	ZHU Yan1
	ZHANG Dan-wei4
	LI Yue-feng1

Cite this article:

ZHANG Ning-ning1,SHENG Liang-ju2,XU Yu-hao3等.

Changes of brain perfusion in first-episode depressive patients and healthy people with family history of depression

[J]. Journal of Jiangsu University(Medicine Edition), 2020, 30(02): 169-172.

URL:

http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2020/V30/I02/169

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