Objective: To explore the related factors of early neurological deterioration (END) in patients with acute isolated pontine infarction(AIPI). Methods: A retrospective analysis of the patients with AIPI was conducted, these patients were treated in the Department of Neurology, Affiliated Hospital of Jiangsu University from January 2016 to January 2019. According to the occurrence of END, the patients were divided into END group and non-END group. The data of patients were collected and the independent risk factors of END in AIPI patients were analyzed by multivariate Logistic regression. Results: There were significant differences in NIHSS score, fasting blood sugar, basilar artery perforator disease and small artery disease between the two groups at admission (all P＜0.05). Basilar artery perforator disease was an independent risk factor for END (OR=5.614，95%CI 1.165~27.055).Conclusion: Basilar artery perforator disease may be attributed to END in patients with AIPI.

［Key words］pontine; cerebral infarction; deterioration of disease; risk factors