核因子E2相关因子2在足月胎膜早破组织中的表达及临床意义

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Abstract Objective: To investigate the relationship between the expression of nuclear erythroid 2related factor 2 (Nrf2) in fetal membranes and the occurrence and development of term prelabor rupture of membrane. Methods: A total of 30 healthy pregnant women as the control group and 30 patients with prelabor rupture of membranes were selected. The expression of Nrf2 mRNA and protein in fetal membranes were detected by qRTPCR and Western blotting. The location and expression of Nrf2 in fetal membranes were detected by immunohistochemistry. Results: Compared with the control group, the expression of Nrf2 mRNA and protein were significantly down-regulated in the prelabor rupture of membranes group(P<0.01 and P<0.05). Immunohistochemistry illustrated that Nrf2 was expressed in the nucleus and cytoplasm of all membrane structures. Compared with the control group, the expression of Nrf2 protein was markedly decreased in the amnion epithelial layer, chorionic trophoblast layer and decidua layer of the prelabor rupture of membranes group(P<0.05 or P<0.01). The expression of Nrf2 was highest in the amnion epithelial layer. Conclusion: The lower expression of Nrf2 in fetal membranes may promote the occurrence and development of prelabor rupture of membranes.

Received: 26 March 2019

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2019/V29/I04/339

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