|
|
|
| Relationship between premature brain injury and the levels of erythropoietin
in cord blood and amniotic fluid
|
| ZHU Hai-tao, Lv Jin-quan, CHANG Ming, WANG Qiu-xia, LU Hong-yan |
| (Department of Pediatrics， Affiliated Hospital of Jiangsu University， Zhenjiang Jiangsu 212001， China)
|
|
|
|
|
Abstract Objective: To explore the predictive value of cord blood and amniotic fluid erythropoietin (EPO) in early brain injury in preterm infants. Methods: A total of 97 cases of premature infants were divided into brain injury group and control group according to the cranial imaging examination， the levels of EPO in cord blood and amniotic fluid were detected by enzyme linked immunosorbent assay (ELISA), then the relationship between premature brain injury and erythropoietin in cord blood and amniotic fluid was evaluated. Results: EPO levels of cord blood and amniotic fluid in brain injury group were significantly higher than those in the control group (both P<0.05).The sensitivity of cord blood EPO in predicting premature brain injury was 83.8% and the specificity was 78.3%.The sensitivity of amniotic fluid EPO in predicting premature brain injury was 75.7% and the specificity was 83.2%. The sensitivity of combined cord blood and amniotic fluid EPO in predicting brain injury was 75.7% and specificity was 93.3%. Conclusion: EPO may be used for the early prediction of brain injury in preterm infants.
|
|
Received: 02 September 2017
|
|
|
|
| ［1］Vora M,Gruslin A. Erythropoietin in obstetrics\[J\]. Obstet Gynecol Surv,1998，53 (8): 500-508.［2］龙莎莎，程国强.早产儿脑白质损伤治疗的循证医学进展\[J\].临床儿科杂志，2015，33(3): 287-290.［3］吕红娟，刘爱敏，薛萍萍.妊娠期糖尿病患者脐血促红细胞生成素含量及其与胎儿缺氧的相关性研究\[J\].中国优生与遗传杂志，2012，20(5):82-83.［4］刘敬，杨于嘉，封志纯.“早产儿脑损伤诊断与防治专家共识”解读\[J\]. 中国当代儿科杂志，2012，14(12): 885-887.［5］李娟，王庆红,吴红敏,等. 2005年中国城市产科新生儿出生状况调查\[J\].中国当代儿科杂志，2012,14(1): 7-10.［6］任青，卢宪梅. 促红细胞生成素与早产儿脑白质损伤的关系研究\[J\].中国妇幼健康研究，2015，26(4):893-895.［7］单继艳，卢红艳，张强，等.不同剂量rhEPO 静注治疗早产儿脑损伤对比观察\[J\]. 山东医药，2016，56(15): 59-61.［8］孙姝，韩英，张楠，等. 重度子痫前期脐血及羊水中促红细胞生成素含量及其与胎儿缺氧的相关性研究\[J\].中国妇幼保健，2006，21(11): 1504-1506.［9］Maier RF，Bhme K, Dudenhausen JW，et al．Cord blood erythropoietinin relation to different markers of fetal hypoxia\[J\].Obstet Gynecol,1993,81(4): 575-580.［10］Eichhorn KH, Bauer C, Eckardt KU,et al．Lack of associations between fetal and maternal serumerythropoietin at birth \[J\]. Eur J Obstet Gynecol Reprod Biol,1993,50(1):47-52.［11］Reisenberger K, Egarter C, Kapiotis S,et al. Transfer of erythropoietin across the placenta perfused in vitro\[J\]. Obstet Gynecol,1997,89(5 Pt 1):738-742.［12］Korzeniewski SJ, Allred E, Logan JW，et al. Elevated endogenous erythropoietin concentrations are associated with increased risk of brain damage in extremely preterm neonates\[J\]. PLoS One，2015,10(3): e0115083.［13］Li Y，Xiao Z，Yan J，et al.Urine erythropoietin level is associated with kidney and brain injury in critically ill neonates\[J\].Neonatology,2013,104(2): 87-94.［14］Juul S.Neuroprotective role of erythropoietin in neonates\[J\]. J Matern Fetal Neonatal Med,2012, 25(Suppl4)：105-107.［15］Juul SE，Pet GC. Erythropoietin and neonatal neuroprotection\[J\]. Clin Perinatol，2015，42(3)：469-481. |
|
|
|
2018, Vol. 28 
