精神分裂症患者外周血白细胞miR-198、miR-206的表达及意义

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Abstract Objective: To evaluate the differences of peripheral blood leucocyte MicroRNA198 (miR198) and MicroRNA206(miR206) levels between schizophrenics and healthy control. Methods: A total of 40 cases of schizophrenics were chosen as case group and 40 healthy people matched with gender and age were selected as control group. The relative expression levels(ΔCt) of peripheral blood leucocyte miR198 and miR206 were measured by real time PCR.Symtomatology of schizophrenics was evaluated by Positive And Negative Syndrome Scale(PANSS). Results: The ΔCt of miR198 and miR206（t=20.363,P<0.01；t=33.762,P<0.01） were higher in the schizophrenics, compared with the healthy control.There were no linear correlation between the relative expression of miR198 or miR206 and PANSS（P>0.05）. Conclusion: The level of peripheral blood leucocyte miR198 and miR206 may be useful for diagnosis and prognosis in schizophrenics.

Received: 24 August 2016

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http://zzs.ujs.edu.cn/xbyxb/EN/ OR http://zzs.ujs.edu.cn/xbyxb/EN/Y2017/V27/I5/420

［1］孙欣羊, 宋红涛, 张梁, 等. 精神分裂症患者血浆MicroRNA异常表达的对照研究\[J\]. 中华行为医学与脑科学杂志, 2013, 22(12): 1095-1098.
［2］Xu Y, Yue W, Yao Shugart Y, et al. Exploring transcription factorsmicroRNAs coregulation networks in schizophrenia\[J\]. Schizophr Bull, 2016, 42(4): 1037-1045.
［3］Geaghan M, Cairns MJ. MicroRNA and posttranscriptional dysregulation in psychiatry\[J\]. Biol Psychiatry, 2015, 78(4): 231-239.
［4］Perkins DO, Jeffries CD, Jarskog LF, et al. microRNA expression in the prefrontal cortex of individuals with schizophrenia and schizoaffective disorder［J］.Genome Biol, 2007,8(2): R27.
［5］Esau CC, Monia BP. Therapeutic potential for microRNAs\[J\]. Adv Drug Deliv Rev, 2007, 59(2/3): 101-114.
［6］Thomas H, Line O, Morten L, et al. Brain expressed microRNAs implicated in schizophrenia etiology\[J\]. PLoS One, 2007, 2(9): e873.
［7］刘平.ICD10 精神与行为障碍分类\[M\]. 北京: 人民卫生出版社, 1995.
［8］司天梅, 杨建中, 舒良,等. 阳性和阴性症状量表(PANSS, 中文版)的信、效度研究\[J\]. 中国心理卫生杂志, 2004, 18(1): 45-47.
［9］Kondo H, Shimono Y, Mukohyama J, et al. Discordance of MCM7 mRNA and its intronic MicroRNA levels under hypoxia\[J\]. Anticancer Res, 2017, 37(7): 3885-3890.
［10］Faravelli I, Corti S. MicroRNAdirected neuronal reprogramming as a therapeutic strategy for neurological diseases\[J\]. Mol Neurobiol, 2017, \[Epub ahead of print\].
［11］Kocerha J, Kauppinen S, Wahlestedt C. microRNAs in CNS disorders\[J\]. Neuromolecular Med, 2009, 11(3): 162-172.
［12］孙欣羊. 精神分裂症特异性生物标记物microRNA的临床初步验证\[D\]. 上海：第二军医大学, 2014.
［13］Nafee N, Gouda N. Nucleic acidsbased nanotherapeutics crossing the blood brain barrier\[J\]. Curr Gene Ther, 2017, 17(2): 154-169.
［14］Gardiner E, Beveridge NJ, Wu JQ, et al. Imprinted DLK1DIO3 region of 14q32 defines a schizophreniaassociated miRNA signature in peripheral blood mononuclear cells\[J\]. Mol Psychiatry, 2011, 17(8): 827-840.
［15］Lai CY, Yu SL, Hsieh MH, et al. MicroRNA expression aberration as potential peripheral blood biomarkers for schizophrenia\[J\]. PLoS one, 2011, 6(6):e21635.