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| Response to bronchodilator in patients with different severity chronic obstructive pulmonary disease |
| WANG Yuan-zheng |
| (Department of Respiratory Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang Jiangxi 330000, China) |
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Abstract Objective: To evaluate the differences of flow and volume responses in patients with mild to severe chronic obstructive pulmonary disease (COPD) in bronchodilatation test. Methods: The different changes of forced expiratory volume in one second（FEV1）and forced vital capacity（FVC） in 220 patients over sixtyyearold with mild to very severe COPD (GOLD stageⅠⅣ) were analyzed retrospectively after inhaling salbutamol. Results: After inhaling β2 agonist, FEV1 and FVC of the patients with COPD at stageⅠⅣ increased remarkably, there were significant differences in the changes of FEV1 and FVC between patients with COPD compared with before treatment (P<0.01)．ΔFEV1 at stage ⅠⅡpatients with COPD increased more obviously than stage ⅢⅣ patients with COPD (P<0.01); on the contrary,ΔFVC at stage Ⅲ-Ⅳ patients with COPD improved more markedly than stage ⅠⅡ patients with COPD (P<0.01). Conclusion: There were differences between postbronchodilator flow and volume responses in patients with COPD at different stage．The reversibility of stage ⅠⅡ patients with COPD could be evaluated by FEV1, while stage ⅢⅣ patients with COPD could be evaluated by FVC.
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Received: 29 September 2013
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2014, Vol. 24 
