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| Association between pulse wave velocity and the Framingham risk score in patients with different glucose metabolism status |
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ZHANG Qian1，FU Qiang2，WEI Peng2，ZHONG Jian1，ZHU Ke2 |
| （1. School of Clinical Medicine， Jiangsu University, Zhenjiang Jiangsu 212013； 2. Department of Cardiology, Xuzhou Central Hospital， Xuzhou Jiangsu 221009, China) |
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Abstract Objective: To investigate the relationship between different glucose metabolism status and pulse wave velocity(PWV)，and to further explore PWV with the Framingham risk score(FRS) of 10-year as predictors of cardiovascular disease(CVD). Methods: A total of 105 subjects were divided into three groups：normal glucose tolerance group(G1,n=47);prediabetes group(G2,n=32)，and type 2 diabetes mellitus group(G3，n=26)．General clinical data of subjects in each group were collected，and biochemical parameters were measured.PWV was measured using the Complior SP(pulse wave velocity determinator).FRS was calculated with the lipids excel spreadsheets from Framingham Heart Study homepage.The correlation of different glucose metabolism status ,PWV and FRS in different groups was analyzed and compared. Results: A positive correlation was found between carotid-to-femoral pulse wave velocity(cf-PWV) and impaired glucose regulation,age,SBP，2hPG, carotid-to-radial pulse wave velocity （cr-PWV）.A negative correlation was also evident between cf-PWV and fasting insulin /fasting C-peptide(FIN/Cp). A correlation was found between cr-PWV and sex, or HDL-C(negative). A correlation was also found between FRS and cf-PWV，or FIN/Cp，or Homa-IR(Cp). Conclusion: cf-PWV has a good clinical value as a vascular structure and function indicator for evaluating the 10year risk of CVD.
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Received: 23 January 2014
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2014, Vol. 24 
