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| Relationship between body mass index and islet β cell function under different glucose metabolisms in adults |
| ZOU Cai-yan 1， LIU Xue-kui 1， LIANG Jun 1, WU Qing-qiang 1， SI Dong-qin 1, DOU Lian-jun 1, WANG Beng 1, JIN Xiao 2 |
| （1. Department of Endocrinology, the Central Hospital of Xuzhou, Xuzhou Jiangsu 221009； 2. Clinical School， Xuzhou Medical University, Xuzhou Jiangsu 221004, China) |
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Abstract Objective: To investigate the correlation between body mass index(BMI) and islet β cell function under different glucose metabolism conditions. Methods: We conducted a health examination survey for individuals who were randomly selected from residents living in the area of Xuzhou, China in 2013. A total of 2 082 subjects were included in the present study. Antheropometric measurements, 2-hour plasma glucose of 75 g oral glucose tolerance test(2hOGTT), fasting blood glucose, fasting insulin, serum uric acid and other biomarkers were collected. They were divided into normal glucose metabolism, abnormal glucose metabolism and diabetic group according to the blood glucose levels of the subjects. According to the level of BMI, they were divided into 3 groups: normal group, over weight and obese group.The Homeostasis Model Assessment-Insulin Resistance index (HOMA-IR), the Homeostasis Model Assessment of islet β cell (HOMA-β) and the Homeostasis Model Assessment-Insulin Sensitive index(HOMA-ISI) were calculated. Results: The level of age, BMI, waist circumference, systolic bloodpressure, diastolic blood pressure, fasting blood glucose, fasting insulin, 2hOGTT, HbA1c, triglycerides, total cholesterol, and LDL-c were higher in the diabetic group than those of the other two groups. And the difference was statistically significant(P<0.05). In nondiabetic groups, HOMA-β and HOMA-IR were increased with the increase of BMI, but HOMA-ISI was decreased with the increase of BMI(P<0.01).While, in the diabetic group, HOMA-ISI was decreased with the increase of BMI(P<0.01),the trend of HOMA-β and HOMA-IR with BMI was not statistically significant. Conclusion: The association of BMI with the function of islet β cells depends on glucose metabolic conditions. In the normal glucose metabolism and abnormal glucose metabolism, higher BMI is associated with the increased islet β cell function. However this association disappeared in the diabetes mellitus.
［Key words］body mass index; insulin resistance; islet β cell; diabetes mellitus
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Received: 05 June 2018
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2018, Vol. 28 
