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| Analysis of the MT2A-838G/C and the MCP-1 -2518G/A gene polymorphism in carotid arteriosclerosis |
| PAN Li-li， ZHANG Jun， WEI Jiang, SHI Yuan-ping, FENG Yue-hua, YU Yang， LUO Guang-hua |
| （Department of Comprehensive Laboratory, Affiliated Third Hospital, Soochow University, Changzhou Jiangsu 213003, China） |
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Abstract Objective: To assess the potential association of the MT2A-838G/C and the MCP-1 -2518G/A gene in patients with carotid arteriosclerosis (CA) in Chinese han population of Jiangsu. Method: A total of 103 consecutive patients with a diagnosis of CA and compared with 46 healthy controls. The polymorphism were detected by basequenched probe technique, the genotypes and allele frequencies of MT2A-838G/C and MCP-1-2518G/A were calculated. Results: The genotype GG, GC, CC distribution of MT2A were 50.49%, 36.89%, 12.62% in patients with CA, and were 52.17%, 36.96%, 10.87% in controls, respectively (P>0.05).Allele G and C frequency of MT2A in patients with CA were 70.65%, 29.35%, and were 68.93%, 31.07% in controls, respectively (P>0.05). The genotype AA, AG, GC distribution of MCP-1 were 20.39%, 44.66%, 34.95% in patients with CA, and were 15.22%,52.17%, 32.61% in controls, respectively (P>0.05). Allele A and G frequency of MCP-1 in patients with CA were 41.30%, 58.70%,and were 42.72%,57.28% in controls, respectively (P>0.05). Conclusion: The 838G/C of MT2A gene and the 2518G/A of MCP-1 gene may be not the independent risk factor for CA in Chinese Han population of Jiangsu. ［Key words］carotid arteriosclerosis; metallothioneins; single nucleotide polymorphism
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2013, Vol. 23 
