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Association of serum chemerin with high sensitive C-reactive protein in pe 2 diabetes with metabolic syndrome |
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YUAN Guo-yue, DONG Si-jing, ZHU Tian-yi, QIAN Wei-yun, TANG Bing-qian,YE Jing-jing, ZHANG Cai-li, ZONG Jing |
(Department of Endocrinology, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001, China) |
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Abstract Objective: To investigate serum levels of chemerin in patients with type 2 diabetes mellitus(T2DM)with metabolic syndrome(MS), and to study the association between serum levels of chemerin and highly sensitive C-reactive protein(hs-CRP). Methods: A total of 88 cases were selected, including 28 healthy subjects and 60 T2DM patients which were divided into MS group and non-MS group according to the diagnostic criteria of MS. Oral glucose tolerance test and insulin releasing test were performed, meanwhile, blood lipid, serum chemerin, hs-CRP and other items were measured. Results: Compared with normal control group and nonMS group, the serum chemerin was significantly increased in MS group［(86.47±23.61） vs （60.09±15.32） ng／mL, （86.47±23.61） vs （61.16±17.90） ng／mL, P<0.01,respectively］; The serum hs-CRP in MS group was higher than in non-MS group ［(2.57±1.64） vs （0.98±0.90） mg／L,P<0.01］. Serum chemerin level was positively correlated with body mass index(BMI), waist circumference(WC), waist hip ratio(WHR), diastolic blood pressure(DBP), Fasting insulin(FINS), postprandial serum insulin(PSI), HOMA-IR, HOMA-β, triglyceride and hs-CRP, and negatively correlated with fasting plasma glucose(FPG), postprandial plasma glucose(2hPG), HDL-C. The multiple regression analysis showed hs-CRP, WHR, DBP and HOMA-β were independent related factors in the influence of the serum chemerin levels. Conclusion: T2DM patients with MS tend to have higher serum chemerin and the level of serum chemerin was associated with hs-CRP.
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Received: 23 April 2013
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2013, Vol. 23 
